In 2017 the SANFL held a Women's Football competition consisting of 4 clubs. After missing out on a team, South Adelaide were granted a licence in June 2017 to compete in the 2018 SANFLW season. After building a strong junior Female Football program, the Panthers were expected to hit the ground running. Krissie Steen was selected as the inaugural coach thanks to her experience at AFL and local level. Along side the new coach, Lauren Buchanan and Kristi Harvey were named as the first ever captians of the Women's team 

On February 2nd, 2018 history was made as the first ever South Adelaide Senior Women's team took to Flinders University Stadium against Glenelg. The Panthers would win by 28-points.

South Adelaide would show some outstanding form throughout the 10 game season, only losing one game against North Adelaide.

With a top 3 finals set-up, the Panthers finished top and booked a place in the Grand Final on ANZAC Day at Peter Motley Oval. After a 19-day break for South Adelaide, they faced off against Norwood, who won the inaugural SANFLW Premiership in 2017. 

In what was a fierce battle, the Panthers took the Premiership Cup to Noarlunga after holding off a late charge by the Redlegs by just 5-points.

Cheyenne Hammond was awarded the Best on Ground Medal after an outstanding performance in helping getting the girls over the line. Adelaide Crows AFLW draftee Nikki Gore won the first Senior Women's Best and Fairest Medal. 

After a history making first season, the Panthers would have a large amount of player turnover, which also included their coach moving into the AFLW system. 

However, Rick Watts would step into the role after working under Krissie Steen for a number of years. In 2018, South Adelaide's Junior Girls program again showcased their talent, with 8 Under-17s coming into the senior side along with new recruit Nicole Campbell. Lauren Buchanan would continue on as a solo captain. 

The Panther Cubs produced another solid season, finishing second at the end of the home and away season, having loss just two games. 

In the Second Semi Final, it was a 2018 Grand Final rematch as South Adelaide were up against the red hot favorites in Norwood. However, the Panthers would produce some of their best football of the year and produce a stunning upset to advance to their second convective Grand Final. 

Two weeks later, South Adelaide was joined by North Adelaide at Glenelg Oval for the Grand Final. On a very wet day, the Panthers off the back of Indy Tahau, who was named Best on Ground thanks to her two important goals, controlled the game from the first bounce to claim their Second Women's Premiership, and to become the first team to win back to back Women's Premierships. The following week Czenya Cavouras would be named the 2019 SAFCW Best and Fairest player.